Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs
이중석, Park Weon-Yeong, 차재국, 정의원, 김창성, 이용근, 최성호,
소속 상세정보
이중석 ( Lee Jung-Seok ) - Yonsei University College of Dentistry Department of Periodontology
( Park Weon-Yeong ) - Yonsei University College of Dentistry Department of Periodontology
차재국 ( Cha Jae-Kook ) - Yonsei University College of Dentistry Department of Periodontology
정의원 ( Jung Ui-Won ) - Yonsei University College of Dentistry Department of Periodontology
김창성 ( Kim Chang-Sung ) - Yonsei University College of Dentistry Department of Periodontology
이용근 ( Lee Yong-Keun ) - Yonsei University College of Dentistry Department of Dental Biomaterials and Bioengineering
최성호 ( Choi Seong-Ho ) - Yonsei University College of Dentistry Department of Periodontology
KMID : 0363020120420020050
Abstract
Purpose: This study evaluated histologically the tissue responses to and the effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in a one-wall periodontal-defect model.
Methods: A customized block bone for filling in the standardized periodontal defect was fabricated from prefabricated n-HA powders and a polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony periodontal defects were surgically created at the mandibular second and fourth premolars of five Beagle dogs. In each dog, one defect was filled with block-type HA and the other served as a sham-surgery control. The animals were sacrificed following an 8-week healing interval for clinical and histological evaluations.
Results: Although the sites that received an n-HA block showed minimal bone formation, the n-HA block was maintained within the defect with its original hexahedral shape. In addition, only a limited inflammatory reaction was observed at sites that received an n-HA block, which might have been due to the high stability of the customized block bone.
Conclusions: In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
키워드
Bone substitutes ; Guided tissue regeneration ; Periodontal disease ; Tissue engineering ; Tissue scaffolds
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